The helicase/SANT-associated (HSA) domain is found in eukaryotic proteins, including Helicase SRCAP/p400/DOM [ PUBMED:16024792 ], Probable global transcription activator SNF2L2/brahma-homologue and Chromatin modification-related protein EAF1 [ PUBMED:15045029 … expand

The helicase/SANT-associated (HSA) domain is found in eukaryotic proteins, including Helicase SRCAP/p400/DOM [ PUBMED:16024792 ], Probable global transcription activator SNF2L2/brahma-homologue and Chromatin modification-related protein EAF1 [ PUBMED:15045029 ]. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [ PUBMED:16024792 ].HSA was initially predicted to be a DNA-binding domain [ PUBMED:11779830 ], but it was later reported to be responsible for the binding to nuclear actin-related proteins (ARPs) and actin [ PUBMED:18408732 ]. In addition to the SANT and helicase domains, the HSA domain is also found in association with the bromo domain [ PUBMED:11779830 ].