HTH_ASNC helix_turn_helix ASNC type
SMART ACC:	SM000344
Description:	AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)
InterPro ACC:	IPR019888
InterPro abstract:	The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One such family is the AsnC/Lrp subfamily [ PUBMED:7770911 ]. The Lrp family of transcriptional regulators appears to be widely distributed among … expand The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One such family is the AsnC/Lrp subfamily [ PUBMED:7770911 ]. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria and archaea, as an important regulatory system of the amino acid metabolism and related processes [ PUBMED:12675791 ]. This entry also includes some siroheme decarboxylases, which contain the AsnC-like ligand binding domain. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 72 894 HTH_ASNC domains in 70 987 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing HTH_ASNC domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing HTH_ASNC domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the HTH_ASNC domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a HTH_ASNC domain which could be assigned to a KEGG orthologous group, and not all proteins containing HTH_ASNC domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

PROSITE	HTH_ASNC_FAMILY
InterPro	IPR019888
Pfam	ASNC_trans_reg