HTH_DTXR Helix-turn-helix diphteria tox regulatory element
SMART ACC:	SM000529
Description:	iron dependent repressor
InterPro ACC:	IPR022689
InterPro abstract:	This entry represents a group of iron dependent repressors, including MntR, IdeR and diphtheria toxin repressor. The diphtheria toxin repressor protein (DTXR) is a member of this group [ PUBMED:7568230 ]. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding … expand This entry represents a group of iron dependent repressors, including MntR, IdeR and diphtheria toxin repressor. The diphtheria toxin repressor protein (DTXR) is a member of this group [ PUBMED:7568230 ]. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [ PUBMED:7743135 ]. collapse
GO process:	regulation of DNA-templated transcription (GO:0006355)
GO function:	transition metal ion binding (GO:0046914), DNA-binding transcription factor activity (GO:0003700)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 14 037 HTH_DTXR domains in 14 034 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing HTH_DTXR domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing HTH_DTXR domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the HTH_DTXR domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a HTH_DTXR domain which could be assigned to a KEGG orthologous group, and not all proteins containing HTH_DTXR domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR022689
Pfam	Fe_dep_repress