 ICA69Islet cell autoantigen ICA69, C-terminal domain | |
|---|---|
| SMART ACC: | SM001237 |
| Description: | This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus (PMID:8975715). Its precise function is unknown. |
| InterPro ACC: | IPR006723 |
| InterPro abstract: | This entry represents a C-terminal domain found in islet cell autoantigen Ica1. Ica1 has been identified as an islet cell autoantigen in type I diabetes mellitus [ PUBMED:8975715 ]. Its precise function is unknown, though it may play a role in neurotransmitter secretion [ PUBMED:11029035 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 020 ICA69 domains in 1 020 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing ICA69 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing ICA69 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the ICA69 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a ICA69 domain which could be assigned to a KEGG orthologous group, and not all proteins containing ICA69 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.