IKKbetaNEMObind I-kappa-kinase-beta NEMO binding domain
SMART ACC:	SM001239
Description:	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with S_TKc. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.
InterPro ACC:	IPR022007
InterPro abstract:	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with IPR000719. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory … expand This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with IPR000719. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO. collapse
GO function:	IkappaB kinase activity (GO:0008384)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 606 IKKbetaNEMObind domains in 603 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing IKKbetaNEMObind domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing IKKbetaNEMObind domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Signalling

Relevant references for this domain

Primary literature for the IKKbetaNEMObind domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a IKKbetaNEMObind domain which could be assigned to a KEGG orthologous group, and not all proteins containing IKKbetaNEMObind domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR022007
Pfam	IKKbetaNEMObind