 Mad3_BUB1_IMad3/BUB1 hoMad3/BUB1 homology region 1 | |
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| SMART ACC: | SM000777 |
| Description: | Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p. |
| InterPro ACC: | IPR013212 |
| InterPro abstract: | Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of Bub1 and Mad3 to Cdc20 [ PUBMED:10704439 ]. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 311 Mad3_BUB1_I domains in 2 307 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Mad3_BUB1_I domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Mad3_BUB1_I domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Replication |
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Relevant references for this domain
Primary literature for the Mad3_BUB1_I domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Mad3_BUB1_I domain which could be assigned to a KEGG orthologous group, and not all proteins containing Mad3_BUB1_I domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| InterPro | IPR013212 |
|---|---|
| Pfam | Mad3_BUB1_I |