 MutL_CMutL C terminal dimerisation domain | |
|---|---|
| SMART ACC: | SM000853 |
| Description: | MutL and MutS are key components of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation. |
| InterPro ACC: | IPR014790 |
| InterPro abstract: | MutL and MutS are key components of the DNA repair machinery that corrects replication errors [ PUBMED:8811176 ]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair. The N-terminal region of MutL contains the ATPase domain and … expand |
| GO process: | mismatch repair (GO:0006298) |
| GO function: | ATP binding (GO:0005524) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 20 111 MutL_C domains in 20 108 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing MutL_C domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing MutL_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the MutL_C domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a MutL_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing MutL_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.