PB1 PB1 domain
SMART ACC:	SM000666
Description:	Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold, similar to that found in ubiquitin and Ras-binding domains. A motif, variously termed OPR, PC and AID, represents the most conserved region of the majority of PB1 domains, and is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers, although not all PB1 domain pairs associate.
InterPro ACC:	IPR000270
InterPro abstract:	The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [ PUBMED:17726178 PUBMED:15590654 … expand The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [ PUBMED:17726178 PUBMED:15590654 PUBMED:11483498 PUBMED:24706860 ]. collapse
GO function:	protein binding (GO:0005515)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 11 243 PB1 domains in 11 222 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PB1 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PB1 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Signalling
Binding / catalysis:	Homodimerisation

Relevant references for this domain

Primary literature for the PB1 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PB1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing PB1 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000270