PLAc Cytoplasmic phospholipase A2, catalytic subunit
SMART ACC:	SM000022
Description:	Cytosolic phospholipases A2 hydrolyse arachidonyl phospholipids. Family includes phospholipases B isoforms.
InterPro ACC:	IPR002642
InterPro abstract:	This family consists of lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 which also has a C2 domain IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in … expand This family consists of lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 which also has a C2 domain IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells [ PUBMED:8027085 ]. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca ²⁺ and selectively hydrolyses arachidonyl phospholipids [ PUBMED:8051052 ], the aligned region corresponds the carboxy-terminal Ca ²⁺ -independent catalytic domain of the protein as discussed in [ PUBMED:8051052 ]. collapse
GO process:	phospholipid catabolic process (GO:0009395)
GO function:	phospholipase activity (GO:0004620)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 4 116 PLAc domains in 4 116 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PLAc domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PLAc domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Binding / catalysis:	Phosphatidylcholine 2-acylhydrolase, lysophospholipase

Relevant references for this domain

Primary literature for the PLAc domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PLAc domain which could be assigned to a KEGG orthologous group, and not all proteins containing PLAc domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR002642