POLBc

POLBc

DNA polymerase type-B family
SMART ACC:SM000486
Description:DNA polymerase alpha, delta, epsilon and zeta chain (eukaryota), DNA polymerases in archaea, DNA polymerase II in e. coli, mitochondrial DNA polymerases and and virus DNA polymerases
InterPro ACC:IPR006172
InterPro abstract:

DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases ( EC:2.7.7.7 ) by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the … expand

GO function:nucleic acid binding (GO:0003676), nucleotide binding (GO:0000166), DNA-directed DNA polymerase activity (GO:0003887)
Family alignment:View the Family alignment or the Alignment consensus sequence
There are 13 646 POLBc domains in 13 642 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing POLBc domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing POLBc domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:Replication

Relevant references for this domain

Primary literature for the POLBc domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a POLBc domain which could be assigned to a KEGG orthologous group, and not all proteins containing POLBc domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

PfamDNA_pol_B
InterProIPR006172
PROSITEDNA_POLYMERASE_B