 PSPproline-rich domain in spliceosome associated proteins | |
|---|---|
| SMART ACC: | SM000581 |
| Description: | - |
| InterPro ACC: | IPR006568 |
| InterPro abstract: | PSP is a proline-rich domain of unknown function found in spliceosome associated proteins. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 532 PSP domains in 2 527 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing PSP domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PSP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Binding / catalysis: | RNA- or snRNP-binding |
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Relevant references for this domain
Primary literature for the PSP domain is listed below. Automatically-derived, secondary literature is also available.
Disease genes where sequence variants are found in this domain
UniRef sequences and OMIM curated human diseases associated with missense mutations within the PSP domain.
| Protein | Description | Disease / phenotype |
|---|---|---|
| MYF6_HUMAN | OMIM:159991 : Myopathy, centronuclear | |
| OMIM:160150 : Becker muscular dystrophy modifier | ||
| OMIM:310200 : no description |
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PSP domain which could be assigned to a KEGG orthologous group, and not all proteins containing PSP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| InterPro | IPR006568 |
|---|