Prim_Zn_Ribbon Zinc-binding domain of primase-helicase
SMART ACC:	SM000778
Description:	This region represents the zinc binding domain. It is found in the N-terminal region of the bacteriophage P4 alpha protein, which is a multifunctional protein with origin recognition, helicase and primase activities.
InterPro ACC:	IPR013237
InterPro abstract:	This entry is represented by bacteriophage T7 DNA helicase/primase (also known as Gp4), an ATP-dependent DNA helicase and primase that is essential for viral DNA replication and recombination [ PUBMED:21606333 PUBMED:22977246 expand This entry is represented by bacteriophage T7 DNA helicase/primase (also known as Gp4), an ATP-dependent DNA helicase and primase that is essential for viral DNA replication and recombination [ PUBMED:21606333 PUBMED:22977246 PUBMED:32009150 ]. Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present [ PUBMED:9139692 ]. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This entry represents a zinc binding domain found in the N-terminal region of the bacteriophage T7 Gp4 and P4 alpha protein. P4 is a multifunctional protein with origin recognition, helicase and primase activities [ PUBMED:8253092 PUBMED:9185573 PUBMED:10892646 ]. collapse
GO function:	helicase activity (GO:0004386), zinc ion binding (GO:0008270)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 2 446 Prim_Zn_Ribbon domains in 2 445 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Prim_Zn_Ribbon domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Prim_Zn_Ribbon domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Replication

Relevant references for this domain

Primary literature for the Prim_Zn_Ribbon domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Prim_Zn_Ribbon domain which could be assigned to a KEGG orthologous group, and not all proteins containing Prim_Zn_Ribbon domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	Prim_Zn_Ribbon
InterPro	IPR013237