 Pro_CACarbonic anhydrase | |
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| SMART ACC: | SM000947 |
| Description: | Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate (PUBMED:1740425). In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation (PUBMED:1584776). Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's. |
| InterPro ACC: | IPR001765 |
| InterPro abstract: | Carbonic anhydrases ( EC:4.2.1.1 ) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide.In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of … expand |
| GO function: | carbonate dehydratase activity (GO:0004089), zinc ion binding (GO:0008270) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 27 781 Pro_CA domains in 27 746 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Pro_CA domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Pro_CA domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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Relevant references for this domain
Primary literature for the Pro_CA domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Pro_CA domain which could be assigned to a KEGG orthologous group, and not all proteins containing Pro_CA domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.