 RABRab subfamily of small GTPases | |
|---|---|
| SMART ACC: | SM000175 |
| Description: | Rab GTPases are implicated in vesicle trafficking. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 39 024 RAB domains in 38 982 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing RAB domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RAB domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Binding / catalysis: | GTP-hydrolysis |
|---|
Relevant references for this domain
Primary literature for the RAB domain is listed below. Automatically-derived, secondary literature is also available.
Disease genes where sequence variants are found in this domain
UniRef sequences and OMIM curated human diseases associated with missense mutations within the RAB domain.
| Protein | Description | Disease / phenotype |
|---|---|---|
| RASH_HUMAN | OMIM:190020 : Bladder cancer | |
| OMIM:109800 : no description | ||
| RASN_HUMAN | OMIM:164790 : Colorectal cancer | |
| RRAS2_HUMAN | OMIM:600098 : ONCOGENE TC21 | |
| A0A024RAV5_HUMAN | OMIM:190070 : Colorectal adenoma ; Colorectal cancer | |
| RB27A_HUMAN | OMIM:603868 : Griscelli syndrome | |
| OMIM:214450 : no description | ||
| RASK_HUMAN | OMIM:190070 : Colorectal adenoma ; Colorectal cancer |
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RAB domain which could be assigned to a KEGG orthologous group, and not all proteins containing RAB domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.