 RICTOR_NRapamycin-insensitive companion of mTOR, N-term | |
|---|---|
| SMART ACC: | SM001308 |
| Description: | Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin. |
| InterPro ACC: | IPR028267 |
| InterPro abstract: | The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 [ PUBMED:15268862 ]. There is a regulatory link between … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 418 RICTOR_N domains in 1 418 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing RICTOR_N domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RICTOR_N domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the RICTOR_N domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RICTOR_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing RICTOR_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.