 RTC4RTC4-like domain | |
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| SMART ACC: | SM001312 |
| Description: | This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres PMID:18845848. This domain is also found in proteins that contain a DNA-binding myb domain. |
| InterPro ACC: | IPR028094 |
| InterPro abstract: | This entry represents the C-terminal domain of the RTC4 (restriction of telomere capping protein 4) protein from yeasts. In Saccharomyces cerevisiae, deletion of RTC4 affects the cell response to telomere uncapping [ PUBMED:18845848 ]. This domain is also found in proteins that contain a DNA-binding myb domain. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 350 RTC4 domains in 350 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing RTC4 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RTC4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the RTC4 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RTC4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing RTC4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.