RasGAP GTPase-activator protein for Ras-like GTPases
SMART ACC:	SM000323
Description:	All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position. Improved domain limits from structure.
InterPro ACC:	IPR001936
InterPro abstract:	This entry represents a conserved domain in the RasGAPs (Ras GTPase-activating proteins). This domain is also known as the RasGAP domain. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP [ PUBMED:1898771 ]. This intrinsic GTPase activity of Ras is regulated … expand This entry represents a conserved domain in the RasGAPs (Ras GTPase-activating proteins). This domain is also known as the RasGAP domain. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP [ PUBMED:1898771 ]. This intrinsic GTPase activity of Ras is regulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins [ PUBMED:1883874 PUBMED:7945277 ]. RasGAP proteins are usually quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or RasGAP domain. The most conserved region within this domain contains a 15 residue motif which seems to be characteristic of this family of proteins [ PUBMED:1883874 ]. collapse
GO process:	regulation of GTPase activity (GO:0043087)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 8 958 RasGAP domains in 8 955 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing RasGAP domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RasGAP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Signalling
Binding / catalysis:	Protein-binding, Ras-binding, GTPase-activatin

Relevant references for this domain

Primary literature for the RasGAP domain is listed below. Automatically-derived, secondary literature is also available.

Disease genes where sequence variants are found in this domain

UniRef sequences and OMIM curated human diseases associated with missense mutations within the RasGAP domain.

Protein	Description	Disease / phenotype
NF1_HUMAN		OMIM:162200 : Neurofibromatosis, type 1 ; Watson syndrome
NF1_HUMAN		OMIM:193520 : Leukemia, juvenile myelomonocytic ; Melanoma, desmoplastic neurotropic

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RasGAP domain which could be assigned to a KEGG orthologous group, and not all proteins containing RasGAP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	RasGAP
PROSITE	RAS_GTPASE_ACTIV_2
InterPro	IPR001936