 RasGEF_N_2Rapamycin-insensitive companion of mTOR RasGEF_N domain | |
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| SMART ACC: | SM001303 |
| Description: | Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin. |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 502 RasGEF_N_2 domains in 1 502 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing RasGEF_N_2 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RasGEF_N_2 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the RasGEF_N_2 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RasGEF_N_2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing RasGEF_N_2 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| Pfam | RasGEF_N_2 |
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