 SPT16FACT complex subunit (SPT16/CDC68) | |
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| SMART ACC: | SM001286 |
| Description: | Proteins in this family are subunits the FACT complex. The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin PMID:15987999. |
| InterPro ACC: | IPR013953 |
| InterPro abstract: | This entry represents a domain found in the central region of Spt16 from diverse eukaryotes [ PUBMED:21454601 PUBMED:33846633 ]. This entry covers the dimerization domain (DD), which straddles nucleosomal DNA at the H2A-H2B dyad [ expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 690 SPT16 domains in 1 688 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing SPT16 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing SPT16 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the SPT16 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a SPT16 domain which could be assigned to a KEGG orthologous group, and not all proteins containing SPT16 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.