 Spt4Spt4/RpoE2 zinc finger | |
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| SMART ACC: | SM001389 |
| Description: | This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 (PMID:8127719). Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles (PMID:11182892). RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved (PMID:19000817). The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery. |
| InterPro ACC: | IPR022800 |
| InterPro abstract: | This entry consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 [ PUBMED:8127719 ]. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 2 181 Spt4 domains in 2 180 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Spt4 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Spt4 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
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Relevant references for this domain
Primary literature for the Spt4 domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Spt4 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Spt4 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.