 TANTelomere-length maintenance and DNA damage repair | |
|---|---|
| SMART ACC: | SM001342 |
| Description: | ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage (PMID:18625723). It is classified as an EC:2.7.11.1. |
| InterPro ACC: | IPR021668 |
| InterPro abstract: | ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings … expand |
| GO function: | protein serine/threonine kinase activity (GO:0004674) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 994 TAN domains in 994 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing TAN domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing TAN domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the TAN domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a TAN domain which could be assigned to a KEGG orthologous group, and not all proteins containing TAN domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.