 Telo_bindTelomeric single stranded DNA binding POT1/CDC13 | |
|---|---|
| SMART ACC: | SM000976 |
| Description: | The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold. |
| InterPro ACC: | IPR011564 |
| InterPro abstract: | This domain binds single stranded telomeric DNA and adopts an OB fold [ PUBMED:11935027 ]. It includes the proteins POT1 and Cdc13 which have been shown to regulate telomere length, replication and capping [ PUBMED:11230149 expand |
| GO process: | telomere maintenance (GO:0000723) |
| GO component: | chromosome, telomeric region (GO:0000781) |
| GO function: | DNA binding (GO:0003677) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 021 Telo_bind domains in 1 020 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Telo_bind domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Telo_bind domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the Telo_bind domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Telo_bind domain which could be assigned to a KEGG orthologous group, and not all proteins containing Telo_bind domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.