 WIFWnt-inhibitory factor-1 like domain | |
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| SMART ACC: | SM000469 |
| Description: | Occurs as extracellular domain in metazoan Ryk receptor tyrosine kinases. C. elegans Ryk is required for cell-cuticle recognition. WIF-1 binds to Wnt and inhibits its activity. |
| InterPro ACC: | IPR003306 |
| InterPro abstract: | Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1WD) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands. This entry represents the WIF domain, it is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is extracellular and contains two conserved cysteines that may form a … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 302 WIF domains in 302 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing WIF domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing WIF domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the WIF domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a WIF domain which could be assigned to a KEGG orthologous group, and not all proteins containing WIF domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| InterPro | IPR003306 |
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