Select your preferred SMART mode:

You can change the mode anytime by simply selecting it in the top right side of any SMART page, or by using the buttons below.

Currently selected mode: none
Normal modeGenomic mode

SMART running modes

You can use SMART in two different modes: normal or genomic. The main difference is in the underlying protein database used.

  • Normal SMART : the database contains the complete Uniprot and the majority of stable Ensembl proteomes.
  • Genomic SMART: only the proteomes of completely sequenced genomes are used, and the protein database is synchronized with the current version of the STRING database. The complete list of genomes in the current version of Genomic SMART is available here.

The protein database in Normal SMART has significant redundancy, even though identical proteins are removed. If you use SMART to explore domain architectures, or want to find exact domain counts in various genomes, consider switching to Genomic mode. The taxonomy breakdown counts in the domain annotation pages will be more accurate, and there will not be many protein fragments corresponding to the same gene in the architecture query results. Remember that you are exploring a limited set of genomes, though.

Different color schemes are used to easily identify the mode you're in:

Normal mode Genomic mode