The Pfam:SIR2_2 domain within your query sequence starts at position 75 and ends at position 225, and its E-value is 7.7e-18.

AAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVI
Pfam:SIR2_2

Pfam:SIR2_2
Pfam domain

Pfam ACC: