The Calx_beta domain within your query sequence starts at position 994 and ends at position 1094, and its E-value is 6.45e-5.

ASLRILRNDDPVYFAEPCVLRVQEGETANFTVLRNGSVDGACTVQYATVDGKASGEEGDFAPVEKGETLVFEVGSREQSISVHVKDDGIPETDEPFYIVLF

Calx_beta Domains in Na-Ca exchangers and integrin-beta4
SMART ACC:	SM000237
Description:	Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
InterPro ACC:	IPR003644
InterPro abstract:	The calx-β motif is present as a tandem repeat in the cytoplasmic domains of Calx Na-Ca exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-β motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in … expand The calx-β motif is present as a tandem repeat in the cytoplasmic domains of Calx Na-Ca exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-β motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif is also found in Fras1/Frem family of extracellular proteins (extracellular matrix organizing protein FRAS1 and FRAS1-related extracellular matrix proteins FRAM1, 2 and 3) required for proper organogenesis during embryonic development and whose mutations lead to Fraser Syndrome, a rare congenital disorder characterised by multisystem malformation usually comprising abnormal brain formation, cryptophthalmos, syndactyly and renal defects [ PUBMED:32333816 ]. This motif contains a series of β-strands and turns that form a self-contained β-sheet [ PUBMED:9294196 PUBMED:10390612 ]. collapse
GO process:	cell communication (GO:0007154)
GO component:	membrane (GO:0016020)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 22 869 Calx_beta domains in 5 347 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Calx_beta domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Calx_beta domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the Calx_beta domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Calx_beta domain which could be assigned to a KEGG orthologous group, and not all proteins containing Calx_beta domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR003644