 AMA-1Apical membrane antigen 1 | |
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| SMART ACC: | SM000815 |
| Description: | Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites. |
| InterPro ACC: | IPR003298 |
| InterPro abstract: | A novel antigen of Plasmodium falciparum has been cloned that contains a hydrophobic domain typical of an integral membrane protein. The antigen is designated apical membrane antigen 1 (AMA-1) by virtue of appearing to be located in the apical complex [ PUBMED:2701947 ]. AMA-1 appears to be transported to the merozoite … expand |
| GO component: | membrane (GO:0016020) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 262 AMA-1 domains in 261 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AMA-1 domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AMA-1 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Interaction (with the environment) |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AMA-1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing AMA-1 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.