 AlcBSiderophore biosynthesis protein domain | |
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| SMART ACC: | SM001006 |
| Description: | AlcB is the conserved 45 residue region of one of the proteins of a complex which mediates alcaligin biosynthesis in Bordetella and aerobactin biosynthesis in E. coli and other bacteria. The protein appears to catalyse N-acylation of the hydroxylamine group in N-hydroxyputrescine with succinyl CoA - an activated mono-thioester derivative of succinic acid that is an intermediate in the Krebs cycle. |
| InterPro ACC: | IPR019432 |
| InterPro abstract: | This entry represents a conserved 45 residue region found in a group of acyltransferases, including MbtK from Mycobacterium tuberculosis [ PUBMED:16461464 ], Ato1 from Omphalotus olearius [ PUBMED:16019163 ], SidL from Neosartorya fumigatus … expand |
| GO process: | siderophore biosynthetic process (GO:0019290) |
| GO function: | acyltransferase activity (GO:0016746) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 7 411 AlcB domains in 7 410 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing AlcB domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AlcB domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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Relevant references for this domain
Primary literature for the AlcB domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AlcB domain which could be assigned to a KEGG orthologous group, and not all proteins containing AlcB domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.