AraC_E_bind Bacterial transcription activator, effector binding domain
SMART ACC:	SM000871
Description:	This domain is found in the probable effector binding domain of a number of different bacterial transcription activators (PUBMED:10802742) and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.
InterPro ACC:	IPR010499
InterPro abstract:	This domain is found in the probable effector binding domain of a number of different bacterial transcription activators [ PUBMED:10802742 ] and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA. … expand This domain is found in the probable effector binding domain of a number of different bacterial transcription activators [ PUBMED:10802742 ] and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA. It is also found in Transcriptional regulator Rob which binds to regulatory regions and represses transcription of genes belonging to the flagellar regulon, including flhD, flhB and fliC [ PUBMED:31501286 PUBMED:18487336 ]. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 24 363 AraC_E_bind domains in 24 326 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing AraC_E_bind domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing AraC_E_bind domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Transcription

Relevant references for this domain

Primary literature for the AraC_E_bind domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a AraC_E_bind domain which could be assigned to a KEGG orthologous group, and not all proteins containing AraC_E_bind domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

Pfam	AraC_E_bind
InterPro	IPR010499