 BATSBiotin and Thiamin Synthesis associated domain | |
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| SMART ACC: | SM000876 |
| Description: | Biotin synthase (BioB), , catalyses the last step of the biotin biosynthetic pathway. The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer (PUBMED:12482614). Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this entry) and form a heterodimer(PUBMED:12650933). Both of these reactions are thought of involve the binding of co-factors, and both function as dimers (PUBMED:12482614), (PUBMED:12650933). This domain therefore may be involved in co-factor binding or dimerisation. |
| InterPro ACC: | IPR010722 |
| InterPro abstract: | This domain is found in biotin synthase and 2-iminoacetate synthase. The latter enzyme is involved in thiamine diphosphate biosynthesis. The reactions catalysed by these enzymes involve the binding of co-factors and both enzymes function as dimers [ PUBMED:12482614 PUBMED:12650933 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 20 794 BATS domains in 20 792 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing BATS domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing BATS domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Interaction (with the environment) |
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Relevant references for this domain
Primary literature for the BATS domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a BATS domain which could be assigned to a KEGG orthologous group, and not all proteins containing BATS domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.