Taxonomic distribution of proteins containing CactinC_cactus domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CactinC_cactus domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Cactin, a conserved protein that interacts with the Drosophila IkappaBprotein cactus and modulates its function.

Lin P, Huang LH, Steward R
Mech Dev. 2000; 94: 57-65

Rel transcription factors function in flies and vertebrates in immunityand development. Although Rel proteins regulate diverse processes, thecontrol of their function is conserved. In a two-hybrid screen foradditional components of the pathway using the Drosophila I-kappaB proteinCactus as a bait, we isolated a novel coiled-coil protein with N-terminalArg-Asp (RD)- like motifs that we call Cactin. Like the other componentsof this pathway, Cactin is evolutionarily conserved. Over-expression ofcactin in a cactus(A2) heterozygous background results in the enhancementof the cactus phenotype. Both the embryonic lethality and ventralizationare strongly increased, suggesting that cactin functions in the Relpathway controlling the formation of dorsal-ventral embryonic polarity.