Taxonomic distribution of proteins containing DELLA domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DELLA domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.

Murase K, Hirano Y, Sun TP, Hakoshima T
Nature. 2008; 456: 459-63

Gibberellins control a range of growth and developmental processes in higherplants and have been widely used in the agricultural industry. By binding to anuclear receptor, GIBBERELLIN INSENSITIVE DWARF1 (GID1), gibberellins regulategene expression by promoting degradation of the transcriptional regulator DELLAproteins, including GIBBERELLIN INSENSITIVE (GAI). The precise manner in whichGID1 discriminates and becomes activated by bioactive gibberellins for specificbinding to DELLA proteins remains unclear. Here we present the crystal structure of a ternary complex of Arabidopsis thaliana GID1A, a bioactive gibberellin andthe amino-terminal DELLA domain of GAI. In this complex, GID1A occludesgibberellin in a deep binding pocket covered by its N-terminal helical switchregion, which in turn interacts with the DELLA domain containing DELLA, VHYNP andLExLE motifs. Our results establish a structural model of a plant hormonereceptor that is distinct from the mechanism of the hormone perception andeffector recognition of the known auxin receptors.