This entry represents a group of eukaryotic and archaeal proteins from the Oxa1 superfamily which includes a group of proteins that function in different contexts as transmembrane domains (TMD) insertases and/or as intramembrane chaperones to facilitate membrane protein folding and assembly [ PUBMED:29281821 expand

This entry represents a group of eukaryotic and archaeal proteins from the Oxa1 superfamily which includes a group of proteins that function in different contexts as transmembrane domains (TMD) insertases and/or as intramembrane chaperones to facilitate membrane protein folding and assembly [ PUBMED:29281821 PUBMED:32820719 ]. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding [ PUBMED:19325107 ], and TMCO1, a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes [ PUBMED:32820719 PUBMED:36261522 ]. Previously, it has been reported that TMCO1 is a ER calcium load-activated calcium channel [ PUBMED:27212239 ]. TMCO1 is required for the normal development of corpus callosum as it plays a role in Ca2 homeostasis [ PUBMED:35927240 ]. Archaeal members may function as insertases of the archaeal plasma membrane [ PUBMED:26256539 ].