This domain is found at the C-terminal of FakA (fatty acid subunit A) protein, which is part of the fatty acid kinase machinery [ PUBMED:36054360 ]. In the human pathogens Staphylococcus and Streptococcus, this system is used to scavenge host fatty acids. FakA is an ATP-binding subunit which interacts with varied FakB … expand

This domain is found at the C-terminal of FakA (fatty acid subunit A) protein, which is part of the fatty acid kinase machinery [ PUBMED:36054360 ]. In the human pathogens Staphylococcus and Streptococcus, this system is used to scavenge host fatty acids. FakA is an ATP-binding subunit which interacts with varied FakB (fatty acid-binding protein) isoforms and synthesises acyl-phosphate from extracellular fatty acids [1]. FakA comprises three domains (FakA_N, FakA_M and FakA_C, ) and resembles an evolutionary mimic of the DhaK-DhaL kinase system. This entry represents FakA_C, which acts as a recipient of fatty acids transferred from FakB in the context of Fak activity [ PUBMED:36054360 ].