Taxonomic distribution of proteins containing FIST_C domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FIST_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

FIST: a sensory domain for diverse signal transduction pathways in prokaryotesand ubiquitin signaling in eukaryotes.

Borziak K, Zhulin IB
Bioinformatics. 2007; 23: 2518-21

MOTIVATION: Sensory domains that are conserved among Bacteria, Archaea andEucarya are important detectors of common signals detected by living cells. Dueto their high sequence divergence, sensory domains are difficult to identify. We systematically look for novel sensory domains using sensitive profile-basedsearches initiated with regions of signal transduction proteins where no knowndomains can be identified by current domain models. RESULTS: Using profilesearches followed by multiple sequence alignment, structure prediction and domainarchitecture analysis, we have identified a novel sensory domain termed FIST,which is present in signal transduction proteins from Bacteria, Archaea andEucarya. Chromosomal proximity of FIST-encoding genes to those coding forproteins involved in amino acid metabolism and transport suggest that FISTdomains bind small ligands, such as amino acids.