GLUCA Glucagon like hormones
SMART ACC:	SM000070
Description:	-
InterPro ACC:	IPR000532
InterPro abstract:	A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of structurally related peptides [ PUBMED:3133967 PUBMED:3291691 ]. Once such hormone, glucagon is widely distributed and produced in the … expand A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of structurally related peptides [ PUBMED:3133967 PUBMED:3291691 ]. Once such hormone, glucagon is widely distributed and produced in the alpha-cells of pancreatic islets [ PUBMED:4076759 ]. It affects glucose metabolism in the liver [ PUBMED:6577439 ] by inhibiting glycogen synthesis, stimulating glycogenolysis and enchancing gluconeogenesis. It also increases mobilisation of glucose, free fatty acids and ketone bodies, which are metabolites produced in excess in diabetes mellitus. Glucagon is produced, like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I and glucagon-like protein II [ PUBMED:3260236 ]. The structure of glucagon itself is fully conserved in all known mammalian species [ PUBMED:4076759 ]. Other members of the structurally similar group include glicentin precursor, secretin, gastric inhibitory protein, vasoactive intestinal peptide (VIP), prealbumin, peptide HI-27 and growth hormone releasing factor. collapse
GO component:	extracellular region (GO:0005576)
GO function:	hormone activity (GO:0005179)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 3 214 GLUCA domains in 1 894 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing GLUCA domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GLUCA domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the GLUCA domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GLUCA domain which could be assigned to a KEGG orthologous group, and not all proteins containing GLUCA domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000532