 HAP1_NHAP1 N-terminal conserved region | |
|---|---|
| SMART ACC: | SM001424 |
| Description: | This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntingtons disease is unclear PMID:7477378,9599014,9285789. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34 PMID:11161814. |
| InterPro ACC: | IPR006933 |
| InterPro abstract: | This entry represents a N-terminal conserved region found in huntingtin-associated protein 1 (HAP1), trafficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and similar proteins from animals [ PUBMED:27737633 ]. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 0 HAP1_N domains in 0 proteins in SMART's NRDB database. | |
Relevant references for this domain
Primary literature for the HAP1_N domain is listed below.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a HAP1_N domain which could be assigned to a KEGG orthologous group, and not all proteins containing HAP1_N domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.