Taxonomic distribution of proteins containing HNS domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing HNS domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli.

Shindo H, Iwaki T, Ieda R, Kurumizaka H, Ueguchi C, Mizuno T, Morikawa S, Nakamura H, Kuboniwa H
FEBS Lett. 1995; 360: 125-31

The three-dimensional structure of the C-terminal domain (47 residues) obtained from the hydrolysis of H-NS protein with bovine trypsin was determined by NMR measurements and distance geometry calculations. It is composed of an antiparallel beta-sheet, an alpha-helix and a 3(10)-helix which form a hydrophobic core, stabilizing the whole structure. This domain has been found to bind to DNA. Possible DNA binding sites are discussed on the basis of the solution structure of the C-terminal domain of H-NS.