This entry represents a SAM-like domain found in fungal mitoribosome protein mS41. The mitochondrion-specific ribosomal protein mS41 family comprises proteins that are integral components of the mitochondrial ribosome, also known as the mitoribosome [ PUBMED:25609543 PUBMED:28154081 … expand

This entry represents a SAM-like domain found in fungal mitoribosome protein mS41. The mitochondrion-specific ribosomal protein mS41 family comprises proteins that are integral components of the mitochondrial ribosome, also known as the mitoribosome [ PUBMED:25609543 PUBMED:28154081 ]. These proteins play a crucial role in the dedicated translation machinery that synthesizes mitochondrial genome-encoded proteins, which include essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are tethered to the mitochondrial inner membrane, ensuring that translation products are cotranslationally integrated into the membrane. Additionally, members of the mS41 family are implicated in the regulation of telomere length, a process essential for maintaining chromosome stability and cellular lifespan. Certain members are also required for survival upon exposure to specific environmental stressors, such as the K1 killer toxin [ PUBMED:12663529 ] and also in telomere length regulation [ PUBMED:16552446 ].