Knot1 Knottins
SMART ACC:	SM000505
Description:	Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins.
InterPro ACC:	IPR003614
InterPro abstract:	Knottins are small proteins characterised by a cystine-knot [ PUBMED:18025039 ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [ PUBMED:15551519 … expand Knottins are small proteins characterised by a cystine-knot [ PUBMED:18025039 ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [ PUBMED:15551519 ]. The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [ PUBMED:8380707 ] and the scorpion alpha and beta-neurotoxins [ PUBMED:12925796 PUBMED:32479835 ]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I. collapse
GO process:	defense response (GO:0006952)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 3 746 Knot1 domains in 3 435 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Knot1 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Knot1 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Knot1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Knot1 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR003614