NAT_PEP Natriuretic peptide
SMART ACC:	SM000183
Description:	Atrial natriuretic peptides are vertebrate hormones important in the overall control of cardiovascular homeostasis and sodium and water balance in general.
InterPro ACC:	IPR000663
InterPro abstract:	Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [ PUBMED:1652921 PUBMED:2536732 ]. There are different NPs that vary … expand Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [ PUBMED:1652921 PUBMED:2536732 ]. There are different NPs that vary in length but share a common core. All are processed from a single precursor. A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP) [ PUBMED:1828035 ]; and green mamba natriuretic peptide (DNP) [ PUBMED:1352773 ]. collapse
GO component:	extracellular region (GO:0005576)
GO function:	hormone activity (GO:0005179)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 1 243 NAT_PEP domains in 1 147 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing NAT_PEP domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing NAT_PEP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a NAT_PEP domain which could be assigned to a KEGG orthologous group, and not all proteins containing NAT_PEP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR000663
PROSITE	NATRIURETIC_PEPTIDE