PKS_AT Acyl transferase domain in polyketide synthase (PKS) enzymes.
SMART ACC:	SM000827
Description:	-
InterPro ACC:	IPR014043
InterPro abstract:	This entry represents the acyl transferase domain in polyketide synthase (PKS) enzymes mainly found in bacteria and eukaryotes. Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( EC:2.3.1.39 ) and eukaryotic fatty acid synthase ( EC:2.3.1.85 … expand This entry represents the acyl transferase domain in polyketide synthase (PKS) enzymes mainly found in bacteria and eukaryotes. Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( EC:2.3.1.39 ) and eukaryotic fatty acid synthase ( EC:2.3.1.85 ) that are involved in fatty acid biosynthesis belong to this group [ PUBMED:19549604 ]. Also included are the polyketide synthases 6-methylsalicylic acid synthase ( EC:2.3.1.165 ), a multifunctional enzyme that involved in the biosynthesis of patulin and conidial green pigment synthase ( EC:2.3.1 ) and several non-reducing polyketide synthases. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 39 850 PKS_AT domains in 31 164 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PKS_AT domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PKS_AT domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PKS_AT domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_AT domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR014043