Taxonomic distribution of proteins containing POLAc domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing POLAc domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Compilation, alignment, and phylogenetic relationships of DNA polymerases.

Braithwaite DK, Ito J
Nucleic Acids Res. 1993; 21: 787-802

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP.

Ollis DL, Brick P, Hamlin R, Xuong NG, Steitz TA
Nature. 1985; 313: 762-6

The 3.3-A resolution crystal structure of the large proteolytic fragment of Escherichia coli DNA polymerase I complexed with deoxythymidine monophosphate consists of two domains, the smaller of which binds zinc-deoxythymidine monophosphate. The most striking feature of the larger domain is a deep crevice of the appropriate size and shape for binding double-stranded B-DNA. A flexible subdomain may allow the enzyme to surround completely the DNA substrate, thereby allowing processive nucleotide polymerization without enzyme dissociation.