 Pro-kuma_activPro-kumamolisin, activation domain | |
|---|---|
| SMART ACC: | SM000944 |
| Description: | This domain is found at the N-terminus of peptidases belonging to MEROPS peptidase family S53 (sedolisin, clan SB). The domain adopts a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptidase (PUBMED:15242607). |
| InterPro ACC: | IPR015366 |
| InterPro abstract: | This domain is found at the N terminus of peptidases belonging to MEROPS peptidase family S53 (sedolisin, clan SB). The domain adopts a ferredoxin-like fold, with an α+β sandwich. Cleavage of the domain results in activation of the peptidase [ PUBMED:15242607 ]. |
| GO function: | serine-type peptidase activity (GO:0008236) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 6 403 Pro-kuma_activ domains in 6 400 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing Pro-kuma_activ domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Pro-kuma_activ domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Pro-kuma_activ domain which could be assigned to a KEGG orthologous group, and not all proteins containing Pro-kuma_activ domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
KEGG orthologous groups
3D structures in PDB containing this domain
Links to other resources describing this domain
| Pfam | Pro-kuma_activ |
|---|---|
| InterPro | IPR015366 |