 SPOB_abSporulation initiation phospho-transferase B, C-terminal | |
|---|---|
| SMART ACC: | SM001317 |
| Description: | Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain, represented by this family. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate hereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. |
| InterPro ACC: | IPR016122 |
| InterPro abstract: | Response regulatory proteins such as sensor kinases control a variety of environmentally induced responses in bacteria. SpoOB is a response regulator that responds to nutritional stress by inducing sporulation. SpoOB is a phosphotransferase that acts upon SpoOA using SpoOF as the phosphor-donor. Phosphorylated SpoOA ca activate sporulation-specific gene transcription [ PUBMED:1664534 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 146 SPOB_ab domains in 146 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing SPOB_ab domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing SPOB_ab domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transcription |
|---|
Relevant references for this domain
Primary literature for the SPOB_ab domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a SPOB_ab domain which could be assigned to a KEGG orthologous group, and not all proteins containing SPOB_ab domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.