 THAP | |
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| SMART ACC: | SM000980 |
| Description: | The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes (PUBMED:12575992). |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 14 352 THAP domains in 12 471 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing THAP domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing THAP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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Relevant references for this domain
Primary literature for the THAP domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a THAP domain which could be assigned to a KEGG orthologous group, and not all proteins containing THAP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.
KEGG pathways
Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.
KEGG orthologous groups
Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.
3D structures in PDB containing this domain
Links to other resources describing this domain
| Pfam | THAP |
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