Taxonomic distribution of proteins containing TLDc domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing TLDc domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Systematic identification of novel protein domain families associated with nuclear functions.

Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
Genome Res. 2002; 12: 47-56

A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.