 TRCF | |
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| SMART ACC: | SM000982 |
| Description: | This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript. |
| InterPro ACC: | IPR005118 |
| InterPro abstract: | The transcription-repair coupling factor (TRCF, product of the mfd gene) couples transcription and DNA repair in bacteria. TRCF removes transcription elongation complexes stalled at DNA lesions and recruits the nucleotide excision repair (NER) machinery to the site. This protein, comprised of eight domains, including region of structurally similar to UvrB, shows to distinct activities: the relief … expand |
| GO process: | DNA repair (GO:0006281) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 21 131 TRCF domains in 21 131 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing TRCF domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing TRCF domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Transport |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a TRCF domain which could be assigned to a KEGG orthologous group, and not all proteins containing TRCF domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.