 WHEP-TRS | |
|---|---|
| SMART ACC: | SM000991 |
| Description: | A conserved domain of 46 amino acids, called WHEP-TRS has been shown (PUBMED:1756734) to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl- tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl- tRNA synthetases (PUBMED:8463296). This domain could contain a central alpha-helical region and may play a role in the association of tRNA-synthetases into multienzyme complexes. |
| InterPro ACC: | IPR000738 |
| InterPro abstract: | A conserved domain of 46 amino acids, called WHEP-TRS has been shown [ PUBMED:1756734 ] to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region … expand |
| GO process: | tRNA aminoacylation for protein translation (GO:0006418) |
| GO function: | ATP binding (GO:0005524), aminoacyl-tRNA ligase activity (GO:0004812) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 6 225 WHEP-TRS domains in 3 507 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing WHEP-TRS domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing WHEP-TRS domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Translation |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a WHEP-TRS domain which could be assigned to a KEGG orthologous group, and not all proteins containing WHEP-TRS domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.