rADc Ribosomal RNA adenine dimethylases
SMART ACC:	SM000650
Description:	-
InterPro ACC:	IPR020598
InterPro abstract:	This entry represents the N-terminal domain of rRNA adenine methylase transferases. The bacterial enzyme KsgA catalyses the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases in 16S rRNA. This enzyme and the resulting modified adenosine bases appear to be conserved in all species of eubacteria, eukaryotes, and archaea, and … expand This entry represents the N-terminal domain of rRNA adenine methylase transferases. The bacterial enzyme KsgA catalyses the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases in 16S rRNA. This enzyme and the resulting modified adenosine bases appear to be conserved in all species of eubacteria, eukaryotes, and archaea, and in eukaryotic organelles. Bacterial resistance to the aminoglycoside antibiotic kasugamycin involves inactivation of KsgA and resulting loss of the dimethylations, with modest consequences to the overall fitness of the organism [ PUBMED:4329247 PUBMED:4336392 PUBMED:6575236 ]. In contrast, the yeast ortholog, Dim1, is essential. In Saccharomyces cerevisiae (Baker's yeast), and presumably in other eukaryotes, the enzyme performs a vital role in pre-rRNA processing in addition to its methylating activity [ PUBMED:15136037 ]. Another orthologue is the eukaryotic transcription factor B (TFB), which has a second function; this enzyme is a nuclear-encoded mitochondrial transcription factor and is essential for mitochondrial gene expression [ PUBMED:23804760 ]. The best conserved region in these enzymes is located in the N-terminal section and corresponds to a region that is probably involved in S-adenosyl methionine (SAM) binding domain. collapse
GO process:	rRNA modification (GO:0000154)
GO function:	rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 25 299 rADc domains in 25 297 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing rADc domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing rADc domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Translation
Binding / catalysis:	RNA-binding

Relevant references for this domain

Primary literature for the rADc domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a rADc domain which could be assigned to a KEGG orthologous group, and not all proteins containing rADc domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR020598
Pfam	RrnaAD